Lucy has problems taking blood from live humans, while J.D. even on his last day still wants to get Dr. Cox’ approval. Meanwhile, Denise is afraid not to be the person with the pants on in her relationship with Drew.
Brick’s teachers tell Frankie and Mike that he is “socially challenged”. Mike believes that enrolling Brick on a basketball team is a good way to get him to interact with others, but the idea falls through. However, when Mike enters the neighborhood block-party lawnmower contest, he realizes that Brick has some special talents. Meanwhile, Frankie joins a booster club in the hopes of raising enough money for Axl’s football team to buy new jerseys, but Axl refuses to give his old one up.
Sam and Dean head to a small town where people are murdered by famous dead icons. However the brothers come to a dead end when two teenagers reveal they saw Paris Hilton kidnap their friend.
Sheldon looks forward to squaring off against the the one actor from the Star Trek universe he holds enmity towards—Wil Wheaton—in a fantasy collectable card game tournament. Wolowitz cashes in on an old pact with Leonard to get Penny to set him up with a friend of hers.
A girl is found stabbed to death in the woods, and her best friend is missing. She is found covered in blood with a knife in her hand, which makes her the prime suspect, but she is suffering from memory loss. Patrick Jane uses his mentalist skills to help find out what really happened.
The Dunder Mifflin staff head to Niagara Falls for Jim and Pam’s wedding, with the understanding that her pregnancy is a forbidden discussion topic, but Jim’s slip of the tongue prods Michael to attempt damage control.
Pam is forced to deal with Andy’s scrotal injury on her wedding night, while Kevin deals with the loss of his dress shoes on the morning of Jim and Pam’s wedding.
Lily and Rufus move up their wedding day, but someone or something will come between them. Can they overcome this and finally get married? Chuck uncovers Carter’s secret. Georgina traps Dan and Vanessa into one of her schemes. Blair suspect something not good about Bree and shares her concerns with Nate.
Michael helps Holly move following her transfer to Nashua, NH. Meanwhile, Pam discovers people at corporate are less enthused about Halloween than she, and Dwight agitates Andrew by applying to Cornell.
Dunder Mifflin decides to produce an ad, but things go awry when Michael hijacks the production. Dwight is busy exploring Second Life, an online website.
It’s initiation time for the full timer Ryan as Dwight takes him out on his first sales call with a side trip to the Schrute family beet farm. Michael is ordered by corporate to log his work activity; and Jim tries to adapt to life at the Stamford branch.