It seems everyone in Tree Hill has something shocking to share: Nathan tells Haley he might want a divorce, Lucas admits to Dan that he saved his life, and Peyton finds out a secret Ellie’s been keeping. Meanwhile, Dan continues to search for the identity of his would-be murderer, and Whitey finds his job security in jeopardy.
Finding difficulties in training his interns, J.D. asks Elliot for some help. She tells J.D. about Sean, who gave Elliot great tips based on his dolphin training that fit perfectly for her interns. Dr. Cox finds the ideal pediatrician for his son: Dr. Norris, who acts and looks just like him. However, Dr. Cox is quick to find a problem with him once Jack develops a cough that scares both him and Jordan.
Clark discovers someone is hunting people affected by the kryptonite rocks and the killer’s next target is Lex. Clark uses his powers to save Lex, but is caught off guard when the killer learns his weakness and shoots him with a kryptonite bullet.
Whistler tells the truth to Michael. Michael tries to get in touch with Sara, but the only phone is in Lechero’s quarters, so he has to rely on T-Bag’s help. Mahone battles his addiction. Bellick steps on some toes.
Jim’s friend Matt returns home with memory loss after serving overseas in the military where all of his friends died. Matt’s comrades appear to Melinda to help Matt regain his memory.
Sam and Dean come in contact with a rabbit’s foot that gives them good luck until a thief steals it from Sam, giving him tons of bad luck. His bad luck continues when he’s kidnapped by the mentor of a hunter who believes he still has his powers.
The staff tries to prevent a patient from getting an elective surgery. Cristina tries to help Preston cope with the after effects of his surgery. A patient bails on their surgery. Someone goes to a bed-and breakfast. Alex deals with a patient who has had a high amount of injuries in the past and believes herself to be a superhero. A man undergoes surgery. Before the surgery his wife was only somewhat supportive, but the results may be too much for her to handle. Izzie tries to go back to the hospital for the first time since Denny died. One child’s constant visits are noted by a nurse. Two foster patients are met with suspicions of child abuse. George and Callie’s relationship moves forward.
HRG and his new partner go to a local bank heist with four villains; including Peter being trapped in one of them. Hiro and Ando track Daphne to Germany, and meet the Haitian. Tracy Strauss goes to New Orleans to find out more information about Niki. Meredith teaches Claire a lesson about fighting. Usutu shows Matt a series of paintings about him.
The CSIs must find the killer after a young woman is pushed in front of a moving bus. Alexx finds a bruise shaped like a hand imprint on the victim’s back, proving that she was pushed in front of the bus, and her boyfriend, Jay Seaver, is the prime suspect. When one of Jay’s office rivals also turns up dead, Jay reveals that he has a psychotic stalker, Claudia, who he thinks might kill to please him. However, when Jay hires a lawyer to protect Claudia, Horatio suspects that Jay may be more involved than they thought. Meanwhile, Calleigh’s father seeks her help when he fears that he may have killed someone after a night of drinking, and Horatio assigns a new CSI, Ryan Wolfe, to the case.
House puts a well-known medical researcher through a battery of tests to determine why he collapsed in his lab. When the team is unable to diagnose the problem, the doctor asks the team to help him end his life. House is forced to use his cane again after the ketamine has worn off as he deals with a clinic patient’s teenage daughter who has a crush on him.